![]() It suggests that CD34 + cells might be important target cells in the autoreactive phenomenon in scleroderma. Furthermore, although detectable in the clinically uninvolved skin of these patients, CD34 + cells were less frequent and more slender than those in normal skin.Ĭonclusion: Immunohistologic staining with anti-CD34 and other antibodies to dermal spindle-shaped cells demonstrated a selective disappearance of CD34 + spindle-shaped cells from the lesions of scleroderma. Even in the study in which cryostat sections were used, CD34 + cells were totally absent from the lesions of scleroderma, while there were numerous proline-4-hydroxylase-positive cells. In contrast, large numbers of factor XIIIa- and procollagen-positive cells were noted in the lesions of scleroderma. Results: CD34 + cells were few or absent in the lesions of scleroderma, while a number of CD34 + cells were found in the lesions of other collagen diseases and in normal skin. Cryostat sections from both involved and uninvolved skin of four patients with scleroderma were also stained with antiCD34, anti-factor XIIIa, and anti-proline-4-hydroxylase antibodies. Spindle cell tumors may be sarcomas or carcinomas. These multinucleated giant cells were positive for tartrate-resistant acid phosphatase, expressed calcitonin receptor, and showed bone-resorption. Intriguingly, even when a filter (pore size: 0.45 microm) was interposed between monocytes and the spindle-shaped cells, polykaryocytes also appeared. When human blood monocytes were co-cultured with these cells, multinucleated giant-cell formation of monocytes was induced. Under a microscope, spindle cells look long and slender. Spindle-shaped cells were established from four giant-cell tumors of bone. To elucidate whether entire populations of dermal fibroblasts or only a subpopulation of cells are involved in the fibrosis of scleroderma, we compared the staining pattern of these antibodies and antiprocollagen antibody in paraffin-embedded skin sections from the lesions of 27 patients with scleroderma and 15 patients with other collagen diseases and from normal skin of 17 subjects. A&P Attached to bones, Skeletal Spindle-shaped cells with ends tapering to points, Smooth Contain intercalated discs and gap junctions, Cardiac Found in. A type of tumor that contains cells called spindle cells, based on their shape. Recently, it has become possible to identify different subpopulations of dermal spindle-shaped cells using anti-CD34 and anti-factor XIIIa antibodies. Background and Design: The pathogenesis of scleroderma is still unknown. ![]()
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